http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012524736-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-08 |
| filingDate | 2009-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012524736-A |
| titleOfInvention | Synthesis of 3-{[(2R) -1-methylpyrrolidin-2-yl] methyl} -5- [2- (phenylsulfonyl) ethyl] 1H-indole |
| abstract | The present invention relates to a drug known under the name eletriptan, 3-{[(2R) -1-methylpyrrolidin-2-yl] methyl} -5- [2- (phenylsulfonyl) ethyl] -1H-indole Or the synthesis of its salts. In particular, the present invention relates to a method for synthesizing eletriptan or a salt thereof, and includes the following steps: a) chlorinating an intermediate of formula (6) using dicarboxylic acid to obtain a derivative salt; b) optional The crude salt obtained according to step a) is purified by solvent crystallization to obtain a purified salt of the intermediate of formula (6), and c) of formula (6) according to step a) Converting the salt of the intermediate, or the purified salt according to step b), to an intermediate of formula (10); and d) converting the intermediate of formula (10) to eletriptan or a salt thereof. Step. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019502761-A |
| priorityDate | 2009-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.