| abstract |
Disclosed are organic compounds that exhibit the ability to inhibit effector toxin secretion or translocation mediated by the bacterial type III secretion system. Disclosed type III secretion system inhibitor compounds include Salmonella species, Shigella flexneri, Pseudomonas species, Yersinia species, enteropathogenic and enteroinvasive Escherichia coli and Chlamydia species having such a type III secretion system Useful to combat infection by gram-negative bacteria. |