http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012520060-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2010-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012520060-A |
| titleOfInvention | Cell-specific effective molecules based on siRNA, application kits for the production of the molecules and use of the molecules |
| abstract | siRNA-based cell-specific effective molecules, application kits for the production of the molecules and use of the molecules. 2.1. An object of the present invention is to form a bond between siRNA and one or more peptides, wherein the siRNA is activated after peptide separation and significantly reduces the biological efficacy of the activated siRNA in the cell. And / or leave no peptide. 2.2. According to the present invention, peptide (3) is coupled to siRNA (2) via a special amino Cn linker, such as amino C6 linker (1). Despite the amino Cn linker remaining in the siRNA and in some cases also leaving peptide residues, it does not reduce or significantly inhibit the biological efficacy of the siRNA. 2.3. The molecule is used, for example, to influence gene expression in an organ or cell, preferably having a disease or infection, or to reduce the expression of a target gene in a cell mixture. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015536146-A |
| priorityDate | 2009-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.