abstract |
The present invention relates to an antisense oligonucleotide that modulates the function and / or expression of a sirtuin 1 (SIRT1) polynucleotide, in particular, a sirtuin 1 (SIRT1) polynucleotide by targeting a natural antisense oligonucleotide of sirtuin 1 (SIRT1). To antisense oligonucleotides that regulate the function and / or expression of The invention also relates to the identification of these antisense oligonucleotides and their use in the treatment of diseases and disorders associated with the expression of SIRT1. |