| abstract |
The present invention treats cancer or viral infections in human patients or other animal hosts, in particular infection by HIV, HCV, Norovirus, Sapolovirus, HSV-1, HSV-2, dengue virus, yellow fever virus, and HBV. It is directed to compounds, compositions and methods for doing or preventing. The compounds are 6-substituted purine monophosphates and pharmaceutically acceptable salts, prodrugs or other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Sapolovirus, HSV-1, HSV-2, dengue virus, yellow fever virus, and HBV. [Selection] Figure 1 |