| abstract |
The present invention relates to a composition comprising a biologically active protein linked to an extended recombinant polypeptide (XTEN), an isolated nucleic acid encoding the composition and vectors and host cells containing it, and glucose-related diseases, metabolic diseases The use of such compositions in the treatment of coagulation disorders, and growth hormone related disorders and conditions. In one aspect, the invention provides an extended recombinant polypeptide (XTEN) composition that enhances the pharmacokinetic properties of the resulting fusion protein when linked to a bioactive protein, and Increase the solubility and stability of the resulting fusion protein, while enhancing the overall biological and / or therapeutic activity of the bioactive protein. |