| abstract |
The present invention includes IL-1α binding proteins. Specifically, the present invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. The antibodies of the present invention have a high affinity for IL-1α and neutralize IL-1α activity. The antibodies of the invention can be full length antibodies or antigen binding portions thereof. Also provided are methods of making the antibodies of the invention and methods of using the antibodies of the invention. The antibodies, or antibody portions, of the invention are useful, for example, for the detection of IL-1α and inhibition of IL-1α activity in human subjects suffering from disorders in which IL-1α activity is detrimental. |