| abstract |
The present invention utilizes carrier particles to present antigenic peptides and proteins to the immune system to induce antigen-specific tolerance. The carrier particles are designed to induce an immune tolerance effect. The present invention is useful for the treatment of immune related disorders such as autoimmune diseases, transplant rejection and allergic reactions. In one embodiment, the present invention provides a composition for inducing antigen-specific tolerance comprising carrier particles having apoptotic signaling molecules and antigenic peptides attached thereto. In another embodiment, the present invention provides a composition for inducing antigen-specific tolerance comprising carrier particles having antigenic peptides attached thereto. In a preferred embodiment, the carrier particles are polystyrene particles. |