http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012514005-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 |
| filingDate | 2009-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012514005-A |
| titleOfInvention | Synthesis of (2-amino) tetrahydrocarbazole-propanoic acid |
| abstract | The present invention provides a novel method for the synthesis of 2-amino-tetrahydrocarbazole-propanoic acid, an important synthetic intermediate for ramatroban. More specifically, the aminocyclohexanol is oxidized to form aminocyclohexanone, the aminocyclohexanone is condensed to form tetrahydrocarbazole, and the tetrahydrocarbazole is deprotected to form a racemic mixture of tetrahydrocarbazole to produce the racemic mixture. The mixture is optically resolved to obtain a product mixture in which one enantiomer is in excess of the other than the other, the excess enantiomer is alkylated to produce an alkyl ester, and the alkyl ester is hydrolyzed to yield 2 -Synthesis of 2-amino-tetrahydrocarbazole-propanoic acid comprising generating amino-tetrahydrocarbazole-propanoic acid. [Selection figure] None |
| priorityDate | 2008-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.