| abstract |
N. meningitidis hemoglobin receptor HmbR in combination with one or more additional antigens, eg, meningococcal outer membrane vesicles and another purified meningococcal antigen (eg, fHBP, 287, NadA , NspA, NhhA, App, Omp85, LOS), conjugated meningococcal capsular saccharide, etc., and used as a vaccine antigen. The invention also produces (i) Neisseria meningitidis highly expressing HmbR, (ii) outer membrane vesicles prepared from such bacteria, and (iii) vesicles derived from such bacteria Provide a way to do it. |