| abstract |
The present invention is for oral administration of a combination dosage form comprising physically separating a tamsulosin dose in the form of an assembly of tamsulosin-containing pellets and a dose of at least one other pharmaceutically active substance. An assembly of tamsulosin-containing pellets comprising tamsulosin hydrochloride uniformly dispersed in a carrier matrix; (i) the pellets in the assembly have a size of less than about 1.4 mm. And advantageously, at least 90% of the pellet has a size greater than 0.30 mm, and (ii) the average content of tamsulosin hydrochloride in the aggregate of pellets is converted based on the dry pellets The assembly, between about 0.15 and 3.00 weight percent, a method of making the pellet assembly, and its use. |