| abstract |
The present invention relates to the fields of materials science and medicine, and relates to agents that can be used as contrast agents, for example for the location of cancer cells. The subject of the present invention is a description of agents that sensitively and selectively identify the location and type of the molecule or cell under investigation. The problem is solved by an agent comprising at least a bioshuttle molecule to which an endohedral fullerene is bound via a peptide-based molecule, wherein the endohedral fullerene is hydrophobic and has the formula A 3-x M x Z @ C 2n [x = 0 to 3, n ≧ 34, A is a rare earth element and / or transuranium element, M is a metal, Z is a nonmetal, and C is carbon]. This problem is further solved by a method in which a hydrophobic endohedral fullerene and a bioshuttle molecule are combined via a Diels-Alder reaction (DAR inv ) that proceeds with reverse electron demand irreversibility. |