http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012508026-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2009-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012508026-A |
| titleOfInvention | Temperature-inducible polynucleotide and use thereof |
| abstract | The present invention is based on the finding that when Chinese hamster ovary (CHO) cells are cultured at temperatures below 37 ° C., the transcriptional activity of both hamster mammary tumor 7 (HMT 7) and hamster reylin genes is increased. The present invention provides a novel genomic sequence of HMT 7, cDNA and protein sequences, and a novel genomic sequence for hamster lilin. These genomic sequences each contain a novel temperature-inducible promoter sequence; two promoter sequences are provided for HMT 7 and one promoter sequence is provided for Lilin. The present invention further provides antisense molecules and siRNA molecules against the nucleic acid molecule of HMT 7. The present invention also provides genetically engineered expression vectors comprising the novel temperature-inducible promoters of the present invention; these are particularly useful as part of a mammalian temperature-inducible expression system. The present invention also provides host cells and / or transgenic animals comprising the novel nucleic acid molecules of the present invention. The invention further provides methods of using the polynucleotides of the invention, for example, for temperature-induced transgene expression. [Selection] Figure 4 |
| priorityDate | 2008-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 273.