abstract |
The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing a fusion protein into mammalian cells, and an anti-apoptotic protein comprising the amino acid sequence of SEQ ID NO: 1 or a variant or fragment having anti-apoptotic activity thereof. . The invention also relates to pharmaceutical compositions comprising such fusion proteins for blocking apoptosis, particularly in patients in need thereof. The invention also provides a polynucleotide encoding such a fusion protein, an expression vector comprising the polynucleotide, and a host cell comprising the expression vector. In a further aspect, the present invention relates to the use of any of these substances to prepare a drug for blocking apoptosis in a patient in need thereof. |