abstract |
The present invention is a dosage form comprising at least one form of tapentadol and at least one opioid antagonist, with or without a second analgesic, wherein tapentadol is present in an optimal or suboptimal amount, Provided is a dosage form in which the antagonist is present in an amount effective to improve the effectiveness of tapentadol and / or reduce the side effects of tapentadol. The invention further provides pain and administration by administering to a patient in need thereof a dosage form comprising at least one form of tapentadol and at least one opioid antagonist, with or without a second analgesic. A method of treating a pain-related condition, wherein tapentadol is present in an optimal or suboptimal amount and the antagonist is effective to improve the effectiveness of tapentadol and / or reduce the side effects of tapentadol To provide a method that exists in |