| abstract |
In the present invention, sirtuin-modulating compounds and methods of use thereof are provided. Sirtuin-modulating compounds are used to increase cell longevity and for example diseases or disorders associated with aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, blood coagulation disorders, inflammation, cancer and / or It may be used to treat and / or prevent a variety of diseases and disorders, including flushing and the like, and diseases or disorders that would benefit from increased mitochondrial activity. Further provided are compositions comprising a sirtuin-modulating compound in combination with other therapeutic agents. |