| abstract |
Granules used in pharmaceutical compositions and the production of pharmaceutical compositions using the granules, wherein the granules are closely associated with at least one pharmaceutically acceptable hydrophilic polymer and have low water solubility (ie , Less than about 1 mg / mL). The granules may contain one or more pharmaceutically acceptable additives such as disintegrants, wetting agents, excipients, binders, lubricants, glidants, colorants and flavoring agents. The present invention also relates to pharmaceutical granules and methods for preparing pharmaceutical compositions comprising the granules. |