| abstract |
The present invention generally relates to inhibitors of glutaminyl peptide cyclotransferase-like protein (QPCTL), and a. Chronic and acute inflammation such as rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis, b. Other inflammatory diseases such as neuropathic pain, graft rejection / non-graft / graft vasculopathy, HIV infection / AIDS, pregnancy toxemia, tuberous sclerosis, Guillain-Barre syndrome, chronic inflammatory Demyelinating multiple radiculopathy and multiple sclerosis, c. Neuroinflammation, and d. A neurodegenerative disease that can result from neuroinflammation, eg, selected from the group consisting of mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down syndrome, familial British dementia, and familial Danish dementia It relates to the use of said inhibitors for the treatment and / or prevention of inflammatory diseases or disorders. [Selection figure] None |