| abstract |
The therapeutic agent, the first polymer, and optionally the second polymer are mixed with an organic solvent to form a first organic phase having a solids content of about 5 to about 50%, the first organic phase being Mixing with the first aqueous solution to form a second phase, emulsifying the second phase to form an emulsion phase, quenching the emulsion phase to form a quenched phase, Add to the quench phase to form a solubilized phase of unencapsulated therapeutic agent, and filter the solubilized phase to recover the target-specific stealth-type nanoparticles for therapeutic use with a diameter of about 80 nm to about 150 nm A method of producing a plurality of therapeutic nanoparticles comprising forming a slurry of nanoparticles. |