| abstract |
The present invention provides an aromatic nitrogen-containing six-membered ring compound having an excellent PDE10 inhibitory action. The present invention provides compounds of formula [I 0 ] [Where: X 1 , X 2 and X 3 are each independently N or CH, and at least two of X 1 , X 2 and X 3 are N; A is * —CH═CH—, * —C (Alk) ═CH—, * —CH 2 —CH 2 — or * —O—CH 2 — ( * is a bond to R 1 ); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R 1 is an optionally substituted nitrogen-containing heterocyclic group, and the nitrogen-containing heterocyclic moiety includes quinoxalinyl, quinolyl, Y is a group selected from the group consisting of isoquinolyl, quinazolinyl, pyrazinyl, pyrimidinyl and a group formed by condensing them with an aliphatic 5- to 6-membered ring; Y 0 is a group consisting of the following (1) to (5) A group selected from: (1) optionally substituted phenyl Is an optionally substituted aromatic monocyclic 5-6 membered heterocyclic group; (2) an optionally substituted aminocarbonyl; (3) an optionally substituted amino lower alkyl; (4) —O —R 2 [wherein R 2 is hydrogen, optionally substituted lower alkyl, lower cycloalkyl, aliphatic monocyclic 5- to 6-membered heterocyclic group, or (5) mono- or di-substituted amino; provided that when Y 0 is mono- or di-substituted amino, the nitrogen-containing heterocyclic moiety of R 1 is not quinoxalinyl or quinolyl] And a pharmacologically acceptable salt thereof, a production method thereof, use of the compound as a PDE10 inhibitor, a pharmaceutical composition containing the compound as an active ingredient, and the like. |