abstract |
The present invention relates to Notch binding agents and Notch antagonists and methods of using agents and / or antagonists to treat diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more types of human Notch receptors, such as Notch2 and / or Notch3, and inhibit tumor growth. Furthermore, the present invention provides a method for treating cancer, comprising the step of administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of human Notch receptor protein and inhibits tumor growth. I will provide a. |