| abstract |
The present invention relates to novel derivatives of epipodophyllotoxin substituted at the 4-position with an optionally substituted (poly) aminoalkylaminoalkylamide, alkyl-urea or alkyl-sulfonamide chain, methods for their preparation, And their use as drugs as anticancer agents. Equation (1) (wherein, R is hydrogen or C 1 - a 4 alkyl, A is, CO (CH 2) n or CONH (CH 2) a n, n = 2, 3, 4 or 5 And R1 and R2 are as described herein). |