| abstract |
Disclosed are compositions and methods for increasing the lifetime of cell cultures and increasing the production of recombinant proteins such as proteins, antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. . Transfection of cells with apoptosis-inhibiting genes or vectors allows cells in culture to survive longer, thereby increasing the state and yield of protein biosynthesis. It is possible to maintain the cells or their increased fractions in culture for a longer period of time as this does not kill the cells due to the expression of apoptosis inhibitors within the cells. |