| abstract |
An object of the present invention is to provide a compound that binds to a kappa opioid receptor with high affinity. Kappa opioid receptor antagonists that produce significant improvements in functional binding assays to kappa opioid receptors, and disease states that are improved by binding of these antagonists to kappa opioid receptors (eg, heroin) Or use in the treatment of cocaine addiction). [Selection figure] None |