abstract |
The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including the GDF-8 (myostatin) receptor, and a functional peptide portion thereof, as well as a virtual representation of the GDF receptor or functional peptide portion thereof. To do. A method for regulating the effect of myostatin on a cell by contacting the cell with a substance that affects myostatin signaling in the cell using a GDF receptor or a functional peptide portion thereof, A method of improving the severity of a pathological condition characterized at least in part by the development of an abnormal amount of metabolic activity of muscle or adipose tissue in a subject by modulating myostatin signaling in cells or adipose tissue cells. A method of modulating the growth of muscle or adipose tissue in a eukaryote by administering to the organism a substance that affects myostatin signaling. [Selection figure] None |