| abstract |
Compositions and methods related to improving the pharmacological properties of biologically active compounds that target the nervous system. A polypeptide having the sequence Sar-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Lys-Lys- (Lys-palm) -Lys-NH2 and An isolated polypeptide comprising an amino acid sequence having at least about 90% identity, or said amino acid sequence having one or more conservative amino acid substitutions. In addition, compositions with high blood-brain barrier permeability are disclosed, including peptides that have high lipophilic properties and high basicity when compared to the unmodified form of the peptide. [Selection] Figure 1 |