| abstract |
The present invention provides a novel composition for overcoming bacterial antibiotic resistance. (2S, 5R) -7-oxo-N-piperidin-4-yl-6- (sulfooxy) -1,6-diazabicyclo [3.2.1] octane-2-carboxamide; and (2S, 5R) -7-oxo-N-[(3S) -pyrrolidin-3-yl] -6- (sulfooxy) -1,6-diazabicyclo [3.2.1] octane-2-carboxamide; And a pharmaceutical composition comprising a β-lactam antibiotic. [In the formula (I), a is a single bond or a double bond, and when a is a single bond, X is CH 2 or the like, and when a is a double bond, X is CH or the like. R 1 is C (O) OR 3 or the like. R 2 is SO 3 M or the like. M is H or the like. R 3 is C 1-8 alkyl or the like. ] [Selection figure] None |