| abstract |
The present invention provides antibodies having antigen binding sites specifically for MN proteins, and methods of using such antibodies in treating and diagnosing MN-related diseases. An antibody, such as a monoclonal antibody or antibody fragment, that binds to cell surface protein MN and can be used in the treatment, prevention and / or diagnosis of cancer. The antibody can further be linked to a cytotoxic agent such as monomethyl auristatin-E and / or co-administered or formulated with one or more additional anticancer agents. Anti-MN antibodies and immunoconjugates can be used to treat and / or diagnose and / or monitor cancer, eg, solid tumors. [Selection figure] None |