| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faf522b8b83eded745c73018576219ba |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4269bf797fad04f40cf5e619074fcc35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fe54dec944b124e78041a0fb814baf4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a2e2ae4bfe8c616331805ccc903b1d9 |
| publicationDate |
2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2012178985-A |
| titleOfInvention |
Screening method for bone mass increasing agent |
| abstract |
An object of the present invention is to provide a screening method for a bone mass increasing agent, characterized in that the evaluation is performed using the degradation property of a vitamin D receptor protein by binding of a test substance as an index. In order to solve the above problems, the present inventors examined the amount of VDR protein in cultured cells derived from wild-type mice and human osteoblasts administered with ED-71. As a result, it was found that the amount of VDR protein was significantly reduced. It was also clarified that this proteolysis is caused by a calpain degradation system, which is a calcium-dependent cysteine protease. Furthermore, it was clarified that VDR to which ED-71 binds interacts with calpain regulatory subunit s1 and is actively degraded. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017524382-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111855851-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111830158-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10696971-B2 |
| priorityDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |