| abstract |
8-[{1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl-1,7-diaza-spiro [4.5] decane-2- A pharmaceutically useful formulation comprising a salt of ON, and a method of treatment using the same. (5S, 8S) -8-[{(1R) -1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8- represented by formula I Disclosed is a pharmaceutical formulation containing a salt of phenyl-1,7-diazaspiro [4.5] decan-2-one. A method of treatment using the dosage form is also disclosed. In one aspect, a crystalline hydrochloride salt of a compound of formula I in a mixture of one or more excipients, optionally one or more 5HT-3 receptor antagonists, and optionally corticosteroids. A granular pharmaceutical formulation comprising is provided. [Selection] Figure 1 |