| abstract |
An aqueous composition for topical administration, comprising a 15-keto-prostaglandin compound having an excellent formulation stability as an active ingredient. An aqueous composition for topical administration comprising a 15-keto-prostaglandin compound as an active ingredient and a polyoxyethylene castor oil derivative as a solubilizer. Examples of the prostaglandin compound include 15-keto-20-ethyl-prostaglandin compound, 15-keto-16,16-difluoro-prostaglandin compound, 15-keto-prostaglandin E compound, and 15-keto. -Preferably it is a prostaglandin F compound. The polyoxyethylene castor oil derivative is preferably polyoxyethylene hydrogenated castor oil 40 or polyoxyethylene hydrogenated castor oil 60. The aqueous composition is preferably blended with a quaternary ammonium type cationic surfactant, particularly benzalkonium chloride or benzethonium chloride. [Selection figure] None |