| abstract |
A retinal degenerative disease model animal that is simple and practical and has few ethical problems, a method for producing the animal, and a method for identifying a candidate substance of a compound that acts on the pathology of retinal degenerative disease using the retinal degenerative disease model I will provide a. [MEANS FOR SOLVING PROBLEMS] A small teleost model of a retinal degenerative disease model, characterized in that the function of actr1b, dynactin3, or dynactin4 gene is deficient or suppressed. In addition, screening methods using these small retinal degeneration models. According to the present invention, it is possible to identify candidate chambers for compounds that act on the pathology of retinal degenerative diseases that are simple and practical, have few ethical problems, and can be evaluated for retinal morphology at high throughput. . [Selection] Figure 1 |