abstract |
Three-component and four-component random amino acid copolymers having lengths of 14, 35, and 50 amino acid residues are provided. FEAK 50-mer is an effective inhibitor against MBP85-99 or proteolipid protein (PLP) 40-60 specific HLA-DR-2 restricted T cell clones. These copolymers effectively suppress EAE developed in susceptible SJL / J (H-2 s ) strains of mice by whole spinal cord homogenate (WSCH) or encephalitogenic epitope PLP139-151. A Y-FAK 50-mer with a molar ratio of approximately Y0.8: F0.2 is more effective than unlabeled MBP85-99 or Copaxone ™ to biotinylated MBP85-99 to HLA-DR-2 molecules. Inhibits epitope binding. [Selection figure] None |