| abstract |
EP4 receptor antagonists with improved EP4 receptor modulator activity useful in the treatment of pain and inflammatory conditions. A compound of formula (I). (In the formula, A represents a phenyl group, B represents an aryl, E represents a 1,4-phenylene group, R 1 and R 2 independently represent a hydrogen atom, R 3 and R 4) Independently represents a hydrogen atom, R 5 represents —CO 2 H, R 6 represents an alkyl group having 1 to 6 carbon atoms, and X represents a methylene group, etc.) [Selection figure] None |