| abstract |
PROBLEM TO BE SOLVED: To detect a cognitive dysfunction disorder including mild cognitive impairment and Alzheimer's disease using a protein and a partial peptide thereof different in abundance in a non-cognitive impairment subject and a cognitive impairment patient, and the protein and the partial peptide Providing a biomarker for detecting cognitive impairment including mild cognitive impairment and Alzheimer's disease. The proteins of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, and partial peptides of these proteins are SEQ ID NOs: 2, 4, 6 From at least one protein selected from the amino acid sequence represented by 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 27 or a peptide fragment having 5 or more amino acid residues generated from the protein A biomarker for diagnosis of a cognitive dysfunction disease and a diagnostic method using the same. [Selection figure] None |