| abstract |
PROBLEM TO BE SOLVED: To provide a diphenyl sulfide derivative useful as a medicament having excellent S1P3 antagonist activity. [MEANS FOR SOLVING PROBLEMS] As a result of intensive studies to create a compound having S1P3 antagonist activity, the general formula (1) [Chemical 1] [In Formula (1), R 1 represents an alkyl group having 1 to 6 carbon atoms or a lower alkoxy group having 1 to 6 carbon atoms which may be substituted with 1 to 3 halogen atoms, and R 2 represents the number of carbon atoms. An alkyl group having 1 to 6 carbon atoms or an alkenyl group having 2 to 6 carbon atoms; R 10 represents an acyl group having 1 to 6 carbon atoms or a carboxyl group; X represents a methylene or oxygen atom; and Z represents a halogen atom. ] It was found that the diphenyl sulfide derivative represented by the formula has excellent S1P3 antagonist activity. [Selection figure] None |