| abstract |
Bicyclic compounds of formula (I), useful as ion channel inhibitors, wherein Z, RN , q, RM , Q, RQ are as defined in claim 1 To provide). The present invention relates to pharmaceutically acceptable compositions comprising compounds and various disorders (eg, acute, chronic, neuropathic or inflammatory pain, arthritis, migraine, cluster headache, trigeminal neuralgia. , Herpes neuralgia, systemic neuralgia, epilepsy or epilepsy state, neurodegenerative disorders, mental disorders such as anxiety and depression, myotony, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence , Visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, root pain, sciatica, back pain, head or neck pain, severe or refractory pain, nociceptive pain, breakthrough pain, postoperative pain, Also provided is a method of using the composition in the treatment of stroke, bipolar disorder, or cancer pain. [Selection figure] None |