| abstract |
A compound having a superior neurokinin NK 1 , neurokinin NK 2 and muscarinic M 3 receptor antagonistic activity and useful as a therapeutic agent for bronchial asthma, chronic obstructive pulmonary disease and the like, or a pharmacologically acceptable salt thereof Offer. The general formula (I) [Wherein R 1 is a hydrogen atom, a C 1 -C 6 alkyl group, etc., R 2 and R 3 are C 1 -C 6 alkyl groups, and R 4 and R 5 are selected from substituent group A. A phenyl group which may be independently substituted with 1 to 5 groups, L 1 is a C 1 -C 10 alkylene group, L 2 is a C 1 -C 10 alkylene group, etc. E is a group of substituents 1 to 4 phenylene groups which may be independently substituted with a group selected from A, such as m is an integer of 1 to 4, n is an integer of 0 to 4, r is 1 or 2, and s is , 0 or 1, substituent group a is, salts halogen atom, C 1 -C 6 alkyl, C 1 -C 6 halogenated alkyl group, acceptable compound or its pharmacologically having a hydroxy group or the like. [Selection figure] None |