| abstract |
Disclosed is a neurokinin NK 1 , neurokinin NK 2 and muscarinic M 3 receptor antagonist. For example, the following formula 1- {2-[(6- {4-[{3-[({[(2S) -1 ′-{2-[(5R) -3-{[3,5-bis (trifluoromethyl) phenyl] ] Carbonyl} -5- (4-fluorophenyl) -1,3-oxazolidine-5-yl] ethyl} -2,3-dihydrospiro [indene-1,4′-piperidin] -2-yl] oxy} acetyl ) (Methyl) amino] propyl} (methyl) carbamoyl] phenoxy} hexanoyl) (methyl) amino] ethyl} piperidin-4-ylbiphenyl-2-ylcarbamate. [Selection figure] None |