abstract |
The present invention provides a method for preventing pregnancy and treating premenstrual syndrome (PMS) including premenstrual dysphoric disease (PMDD). A combined dosage form of estrogen and progestin, preferably monophasically, is administered for 21 to 26 consecutive days, followed by 2 to 10 days in combination with the antidepressant fluoxetine hydrochloride. A dose of estrogen is administered. The daily dose of estrogen and progestin is equivalent to about 5 μg to 50 μg of ethinyl estradiol and about 0.025 mg to 10 mg, preferably about 0.05 mg to 1.5 mg of levonorgestrel, respectively, and fluoxetine hydrochloride is about 5 mg to 120 mg. Is the amount. [Selection figure] None |