| abstract |
A Gla domain variant of human Factor VII or human Factor VIIa polypeptide is provided. SOLUTION: It has 1 to 15 amino acid modifications related to human factor VII or human factor VIIa, and a hydrophobic amino acid residue is introduced by substitution at position 34, or an amino acid substitution at position 36 Or said polypeptide variant having substitutions of amino acids at positions 10 and 32 and at least one further amino acid substitution at a site selected from positions 74, 77 and 116. [Selection] Figure 1 |