http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012102087-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_731a5c14521f8abac80caa8a90045c83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3675c4129371bd9fda5228efc4faf364 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 |
| filingDate | 2011-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df337860927da9056024213ff7a15551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77a008b72e116c4f9f29b29e21695c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc380a4e5b584dd97abfe2a990ff040c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_977a622726af5c1a3d1241bb9985cd02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67705bd2a9d924a8656aa4cc3cfc0a83 |
| publicationDate | 2012-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012102087-A |
| titleOfInvention | Prophylactic / therapeutic agent for diseases containing an inhibitor of protein lysine methylase Set7 / 9 |
| abstract | An object of the present invention is to provide a histone methyltransferase Set7 / 9 inhibitor, a cancer cell growth inhibitor, and a prophylactic / therapeutic agent for diseases caused by excessive estrogen receptor. In order to solve the above problems, the present inventors performed screening by applying a high-throughput HMT activity measurement method originally developed by the inventors, and used cyproheptadine as an inhibitor of Set7 / 9. Identified. Furthermore, cyproheptadine selectively inhibited Set7 / 9 in vitro, reduced the expression level of ERĪ± in breast cancer cells, and suppressed estrogen-dependent growth of breast cancer cells. From this, it was found that a Set7 / 9 inhibitor can be a prophylactic / therapeutic agent for diseases caused by excessive estrogen receptor, and the present invention has been completed. [Selection] Figure 7 |
| priorityDate | 2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 442.