http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012093336-A

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filingDate 2011-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2012093336-A
titleOfInvention Biomolecule detection apparatus and biomolecule detection method
abstract A biomolecule detection apparatus capable of highly sensitive measurement is provided. A configuration capable of switching the orientation directions of free molecules and binding molecules in a solution by switching the vibration direction of orientation control light, and switching the light emission amounts per molecule of the free molecules and binding molecules. did. In addition, since the free molecules 20 and the binding molecules 22 have a difference in the time required for switching the alignment direction due to the switching of the irradiation direction of the alignment control light 117, the timings at which the light emission amounts of the respective molecules increase are different. Therefore, even if all fluorescent molecules in the solution generate fluorescence, it is possible to calculate the contribution of fluorescence associated with each free molecule and binding molecule, and accurately measure the concentration of the target substance with a simple configuration. can do. [Selection] Figure 7B
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