| abstract |
The present invention provides methods, compounds, and compositions useful for the treatment of cancer. Hypoxia activated prodrugs can be used to treat cancer when administered alone or in combination with one or more antineoplastic agents. In one example, the protective antineoplastic agent has the chemical formula Hyp-L-N or Hyp-N, where Hyp is a hypoxic activator; L is a linking group; and N is an antineoplastic agent. It is. Hypoxic activators can be electron deficient nitrobenzene moieties, electron deficient nitrobenzoic acid amide moieties, nitroazole moieties, nitroimidazole moieties, nitrothiophene moieties, nitrothiazole moieties, nitrooxazole moieties, nitrofuran moieties, and nitropyrrole moieties. . [Selection figure] None |