| abstract |
To provide a substance that activates transcription factor Nrf2 (NF-E2 related factor 2) and its use. A compound represented by the following formula (1) or a salt thereof, or a hydrate or solvate thereof has an Nrf2 activating action, so that an Nrf2 activator, an ischemic heart disease, It is useful as a medicament for the prevention or treatment of ischemia reperfusion injury, macular degeneration or cataract. [Chemical 1] [Selection] Figure 1 |