| abstract |
A polyanhydride is provided by linking a low molecular weight drug molecule containing a carboxylic acid group and an amine group, a thiol group, an alcohol group or a phenol group in its structure to form a polymer drug delivery system. In addition to methods of generating polymeric drug delivery systems via these polyanhydride linkers, methods of administering low molecular weight drugs to a host via these polymeric drug delivery systems are also provided. ing. The polyanhydride polymers of the present invention not only exhibit high solubility and processability, but also hydrolyzable linkages (eg, esters, amides, urethanes, carbamates and carbamates as opposed to radical or aliphatic linkages). Decomposition characteristics due to the use of carbonate). [Selection figure] None |