abstract |
Disclosed is a novel VR1 antagonist useful for the treatment of pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity. A compound represented by formula (I). (Wherein, X 1 to X 5 represent a nitrogen atom, R 5 to R 7 , R 8a , R 8b , and R 9 represent a hydrogen atom, Z 1 and Z 2 represent an oxygen atom, L represents alkenylene or the like.) [Selection figure] None |