| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2985 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
| filingDate |
2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_081427ec119a6863f686ffa5b6367668
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d269a1ff6933442f6c03fc95e7e66de0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1f72877fb6dba54b1ffdb14447e540b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_285517f670e077bdc3ce8c26c34bc881 |
| publicationDate |
2012-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2012067143-A |
| titleOfInvention |
Method for producing biodegradable active agent microspheres |
| abstract |
PROBLEM TO BE SOLVED: To produce an intraocularly implantable biodegradable active agent microsphere capable of releasing a therapeutic agent at a sustained or controlled rate over a long period and with little or no negative side effects. provide. A step of preparing a viscous organic phase comprising a TKI having a partition coefficient logP of 4 or more, a biodegradable polymer, and a solvent in a two-phase system composed of n-octanol and water; preparing to have a pH of pH 6 to pH 8; mixing the viscous organic phase and the first aqueous phase to form an emulsion; preparing the second aqueous phase to have a pH of pH 4 to pH 9; Adding a second aqueous phase to the emulsion to form a solution; stirring the solution; evaporating the solvent and producing biodegradable microspheres encapsulating TKI; Degradable microspheres are biodegradable active agent microspheres that release TKI at a rate effective to sustain the release of TKI from the microsphere for a period of more than one month from the time of placement in the vitreous of the eye. Production method. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021119183-A |
| priorityDate |
2004-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |