| abstract |
The present invention relates to a method for selecting a substance having a heat production-enhancing action containing a compound having an action to activate PPARδ, and a drug thereof, and an anti-diabetic, anti-obesity, and visceral accumulated fat reducing function. Provide drugs. The present invention enhances non-shivering thermogenesis (nST) containing a compound having an action of activating the peroxisome proliferator-activated receptor PPARδ, and mitochondria in cells such as adipose tissue. An agent having an action of specifically enhancing uncoupled respiration or proton leak in the inner mitochondrial membrane and increasing the expression level of UCP1, an anti-diabetic agent, an anti-obesity agent and a visceral accumulated fat reducing agent containing the compound is there. The present invention also relates to a method for selecting the compound by measuring PPARδ activation action. [Selection] Figure 1 |