| abstract |
The present invention relates to a method for determining an endogenous factor that regulates the rest period of a hair growth cycle, screening for a substance that inhibits the activity or expression of the endogenous factor, and a hair growth rest period shortening agent or a hair loss preventing agent. FGF18 present in hair follicles is a regulatory factor that regulates the rest period of the hair growth cycle, initiates the shedding period, and further defines the hair cycle domain. A method of screening a FGF18 activity inhibitor or an FGF18 gene expression inhibitor as a candidate for a hair growth rest period shortening agent, a hair loss preventing agent, and a hair leveling agent. In addition, a hair growth resting period shortening agent, a hair loss preventing agent, and a hair level adjusting agent containing an FGF18 activity inhibitory substance and / or an expression inhibitory substance such as a partial peptide of FGF18 and an anti-FGF18 antibody as active ingredients. [Selection figure] None |